Its composition varies according to the topics to be dealt with, although it has five permanent members from each of the representations. The President of the Commission is the State Administration, while the Autonomous Community is the Vice-President. Each representation will be assisted by a Secretary.

Its functions are those provided for in the Operating Regulations adopted on 20 September 2000.

• Promote and concretise, from a bilateral point of view, the implementation of plans, programmes and joint actions for the development of common policies in the different sectoral areas.
• Encourage the conclusion of collaboration agreements in those material areas in which it is necessary to specify a joint plan or program on a bilateral basis.
• Design mechanisms for mutual collaboration in the different areas in which the activity of both Administrations can converge.
• To serve as a channel for preventive actions in the attempt to prevent conflicts between the two Administrations from arising.
• To make proposals for solutions to issues that are of interest to both Administrations in matters within their competence.
• Examine any matters that affect both parties and, in particular, those that aim to avoid or attempt to resolve conflicts of competence through non-procedural means.
• Analyze the norms with the rank of Law, State or autonomous, in relation to which issues are raised that may give rise to the proposal of an appeal of unconstitutionality, in order to reach an agreement that avoids its interposition, within the framework of the provisions of article 33 of Organic Law 2/1979, of October 3, of the Constitutional Court, in the wording given by Organic Law 1/2000, of January 7.